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KMID : 0882420070720050491
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Korean Journal of Medicine
2007 Volume.72 No. 5 p.491 ~ p.500
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Clinical significance of the serum levels of matrix metalloproteinases and the tissue inhibitors of metalloproteinases for gastric and colorectal cancer patients
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Yun Su-Jin
Shim Ki-Nam
Cho Yoo-Kyung
Song Hyun-Joo
Jung Sung-Ae
Kim Tae-Hun
Yoo Kwon
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Abstract
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Background : Matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinase
(TIMPs), are important factors related to invasion and metastasis in various human cancers. Different results have been
reported about the correlation of the serum levels of MMPs and TIMPs and the cancer stages and prognoses in gastric
and colorectal cancer patients. This study was designed to determine whether the serum levels of MMP-2, MMP-9,
TIMP-1 and TIMP-2 are correlated with the pathologic findings and cancer stages.
Methods : This retrospective study included 46 gastric cancer patients, 30 colonic adenoma patients and 46 colorectal cancer patients. The serum levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 were analyzed using an ELISA technique. The pathologic findings of the endoscopic biopsies and the operative specimens, and the clinicopathologic staging were analyzed.
Results : There were no significant differences in the serum levels of MMP-2, MMP-9, TIMP-1 and TIMP-2
according to the pathologic findings and the stages of the gastric and colorectal cancers. However the serum TIMP-1
levels were significantly higher in the advanced gastric cancer patients than in the control group and the early gastric
cancer patients. The serum TIMP-2 levels were higher in the control group than in the tubular adenoma patients, the
tubulovillous adenoma patients and the colorectal cancer patients.
Conclusions : These results suggest that serum levels of TIMP-1 may be a good marker of invasive gastric cancer. The multistep process of colonic tumorigenesis may be modulated by TIMP-2.(Korean J Med 72:491-500, 2007)
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KEYWORD
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Matrix metalloproteinases, Tissue inhibitor of metalloproteinases, Stomach neoplasms, Colorectal neoplasms
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